Sorbus Aucuparia L. Fruit Extract and its Cosmetics – As Promising Agents for Prophylactic and Treatment of Pyodermitis: Phytochemical and Microbiological Research

The problem of acne is relevant. The market mostly represents synthesized substances for prevention and treatment, but medical cosmetics based on plant-origin raw material, especially fruits, can be offered. The fruits of Sorbus aucuparia L. are rich in biologically active substances, which turned out to be unique in solving problems of acne.

The aim of the research was to study the phenolic composition and microbiological activity of the S. aucuparia fruit extract and the proposed medicinal cosmetics to prove the possibility of their use for the treatment of pyodermitis.

The phenolic compounds of the S. aucuparia fruit extract obtained with 70% ethanol solution were studied by HPLC. The microbiological research was carried out by methods of diffusion into agar.

In the S. aucuparia extract gallic acid, gallocatechin, epigallocatechin, catechin, epicatechin, epicatechin gallate, ellagic acid, hyperoside, rutin, quercetin-3-D-glucoside, chlorogenic, caffeic, ferulic and р-coumaric acids, umbelliferone were identified and quantified. The antimicrobial activity of the S. aucuparia extract has been established. The synergism of antimicrobial activity of 1/4 and 1/64 minimal suppression concentration erythromycin against all tested Staphylococci strains was manifested by the extract. Biological active substances of S. aucuparia fruits more effectively restore sensitivity to erythromycin in Staphylococci with low macrolide resistance of Staphylococci (MLS-resistance) due to blocking reflex mechanisms.

The S. aucuparia fruit extracts are rich in phenolic compounds and show antimicrobial activity against all used test-strains of microorganisms. The results of the study indicate their high antimicrobial activity against the main pathogens of pyodermitis - S. aureus, S. epidermidis, and Propionibacterium acnes.