RESEARCH ARTICLE


Disruption of Tight Junction Integrity, and Induced Mammary Involution in Lactating Goats by Saponins



S.J. Mabjeesh*, 1, Z. Kerem2, C. Sabastian1, A. Shamay3
1 Department of Animal Science, Faculty of Agricultural, Food and Environmental Quality Sciences, the Hebrew University of Jerusalem, P.O. Box 12, Rehovot 76100, Israel
2 Institute of Biochemistry, Food Science and Nutrition, Faculty of Agricultural, Food and Environmental Quality Sciences, the Hebrew University of Jerusalem, P.O. Box 12, Rehovot 76100, Israel
3 Agricultural Research Organization (ARO), the Volcani Center, Institute of Animal Science. P.O. Box 6, Bet Dagan, 50250, Israel


Article Metrics

CrossRef Citations:
0
Total Statistics:

Full-Text HTML Views: 1323
Abstract HTML Views: 2337
PDF Downloads: 912
Total Views/Downloads: 4572
Unique Statistics:

Full-Text HTML Views: 666
Abstract HTML Views: 1335
PDF Downloads: 695
Total Views/Downloads: 2696



Creative Commons License
© 2007 Mabjeesh et al.

open-access license: This is an open access article distributed under the terms of the Creative Commons Attribution 4.0 International Public License (CC-BY 4.0), a copy of which is available at: https://creativecommons.org/licenses/by/4.0/legalcode. This license permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.

* Address correspondence to this author at the Department of Animal Science Faculty of Agricultural, Food and Environmental Quality Sciences, the Hebrew University of Jerusalem, P.O. Box 12, Rehovot 76100, Israel; Fax: +972-8-948979; E-mail: mabjeesh@agri.huji.ac.il


Abstract

Four multiparous pregnant Nubian goats at late lactation were subjected to injection of a saponin preparation from Gypsophila roots. Saponin solution was injected into one single gland of each goat after milking 8 times. At day 2 in treatment, milk yield began to be affected, and dropped down dramatically from day 3 till dry off at day 8. The pH value of milk was increased in udder halves treated with the saponin solution after 2 days, whereas the control halves exhibited semi-plateau manner all over the experiment. Sodium concentration increased and potassium concentration decreased after 2 d in treatment. Calcium concentration in the treated udder declined after 8 d and the values of these ions were roundabout the plasma concentrations indicating that milk secreted from the treated udder halves with saponins was mostly composed of interstitial fluid.

Keywords: Mammary gland, saponins, dry up, Gypsophila.