Palm Dates Protect Memory Formation in Diabetes Mellitus: Neutralization of Oxidative Stress
Iyad F. Ghaith1, Karem H. Alzoubi2, 3, *, Tamam El-Elimat4, Nour A. Al-Sawalha3, Omar F. Khabour5, Mahmoud A. Alomari6, Enaam M. Al Momany7, Doa’a G. F. Al U’datt8
Identifiers and Pagination:Year: 2023
E-location ID: e187433152306270
Publisher ID: e187433152306270
Article History:Received Date: 12/04/2023
Revision Received Date: 20/05/2023
Acceptance Date: 31/05/2023
Electronic publication date: 07/08/2023
Collection year: 2023
open-access license: This is an open access article distributed under the terms of the Creative Commons Attribution 4.0 International Public License (CC-BY 4.0), a copy of which is available at: https://creativecommons.org/licenses/by/4.0/legalcode. This license permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
Diabetes Mellitus (DM) is associated with spatial memory impairment that is attributed to the oxidative imbalance in the brain. Palm dates were reported to have neuroprotective and antioxidant effects. This investigation examined palm date consumption for its impact on the decline in cognitive function and oxidative imbalance associated with DM using the streptozotocin (STZ) rat model.
The palm dates extract was administered to rats orally (3.2 g per kg of body weight) for eight weeks. Memory assessment was performed using the Radial Arm Water Maze (RAWM). Hippocampal biomarkers of oxidative stress were evaluated.
STZ-treated animals revealed significant spatial memory impairment (short-and long-term) (P<0.05). Date consumption for eight weeks prevented the decline in spatial memory induced by STZ (P<0.05). STZ administration induced oxidation imbalance in the hippocampus as marked by the significant reduction in the activity of glutathione peroxidase (GPx), reduced glutathione (GSH) levels, and GSH/GSSG ratio as well as raised levels of oxidized glutathione (GSSG) (P<0.05). Date consumption for eight weeks prevented oxidative imbalance induced by STZ in the hippocampus (P<0.05).
This study has verified the beneficial effect of palm dates on cognitive impairment and oxidative imbalance associated with DM.