RESEARCH ARTICLE


Palm Dates Protect Memory Formation in Diabetes Mellitus: Neutralization of Oxidative Stress



Iyad F. Ghaith1, Karem H. Alzoubi2, 3, *, Tamam El-Elimat4, Nour A. Al-Sawalha3, Omar F. Khabour5, Mahmoud A. Alomari6, Enaam M. Al Momany7, Doa’a G. F. Al U’datt8
1 Department of Legal Medicine, Toxicology and Forensic Sciences, Faculty of Medicine, Jordan University of Science and Technology, Irbid 22110, Jordan
2 Department of Pharmacy Practice and Pharmacotherapeutics, College of Pharmacy, University of Sharjah, Sharjah, UAE
3 Department of Clinical Pharmacy, Jordan University of Science and Technology, Irbid 22110, Jordan
4 Department of Medicinal Chemistry and Pharmacognosy, Faculty of Pharmacy, Jordan University of Science and Technology, Irbid 22110, Jordan
5 Department of Medical Laboratory Sciences, Jordan University of Science and Technology, Irbid 22110, Jordan
6 Department of Rehabilitation Sciences, Jordan University of Science and Technology, Irbid 22110, Jordan
7 Department of Clinical Pharmacy and Pharmacy Practice, Faculty of Pharmaceutical Sciences, The Hashemite University, P.O. Box 330127, Zarqa 13133, Jordan
8 Department of Physiology and Biochemistry, Faculty of Medicine, Jordan University of Science and Technology, Irbid 22110, Jordan

Article Information


Identifiers and Pagination:

Year: 2023
Volume: 17
E-location ID: e187433152306270
Publisher ID: e187433152306270
DOI: 10.2174/18743315-v17-230726-2023-29

Article History:

Received Date: 12/04/2023
Revision Received Date: 20/05/2023
Acceptance Date: 31/05/2023
Electronic publication date: 07/08/2023
Collection year: 2023

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Creative Commons License
© 2023 Ghaith et al.

open-access license: This is an open access article distributed under the terms of the Creative Commons Attribution 4.0 International Public License (CC-BY 4.0), a copy of which is available at: https://creativecommons.org/licenses/by/4.0/legalcode. This license permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.

* Address correspondence to this author at the Faculty of Pharmacy, Jordan University of Science and Technology, Irbid 22110, Jordan; Tel: +962-2-7201000; Ext.: 23521, Fax: +962-2-7201087; E-mail: khalzoubi@just.edu.jo


Abstract

Background:

Diabetes Mellitus (DM) is associated with spatial memory impairment that is attributed to the oxidative imbalance in the brain. Palm dates were reported to have neuroprotective and antioxidant effects. This investigation examined palm date consumption for its impact on the decline in cognitive function and oxidative imbalance associated with DM using the streptozotocin (STZ) rat model.

Methods:

The palm dates extract was administered to rats orally (3.2 g per kg of body weight) for eight weeks. Memory assessment was performed using the Radial Arm Water Maze (RAWM). Hippocampal biomarkers of oxidative stress were evaluated.

Results:

STZ-treated animals revealed significant spatial memory impairment (short-and long-term) (P<0.05). Date consumption for eight weeks prevented the decline in spatial memory induced by STZ (P<0.05). STZ administration induced oxidation imbalance in the hippocampus as marked by the significant reduction in the activity of glutathione peroxidase (GPx), reduced glutathione (GSH) levels, and GSH/GSSG ratio as well as raised levels of oxidized glutathione (GSSG) (P<0.05). Date consumption for eight weeks prevented oxidative imbalance induced by STZ in the hippocampus (P<0.05).

Conclusion:

This study has verified the beneficial effect of palm dates on cognitive impairment and oxidative imbalance associated with DM.

Keywords: Palm dates, Memory, Learning, Diabetes mellitus, STZ, Hippocampus, Oxidative stress.